Bovine serum albumin protected gold nanozymes as a novel anti-cancer nanodrug for acute T-type lymphoblastic leukemia treatment via effect on the expression of anti-apoptotic genes

Abstract In this paper, the bovine serum albumin protected gold nanozymes (BSA-Au nanozymes) were utilized as a novel nanodrug for treatment of acute T-type lymphoblastic leukemia (Jurkat) by production excessive ROS and effect on expression anti-apoptotic genes. The BSA-Au Bcl-2 survivin in Jurkat cell line was checked. results showed that genes significantly reduced after with (p-value 0.001) potential while their normal PBMC not affected nanodrug. Moreover, cytotoxic developed evaluated which illustrated survival rate studied reaches its minimum value (100% lethality, 0.0% survival) 48 h. IC50 calculated at 0.05 mM Overall, can be used via reducing genes, increasing common anticancer drugs such Adriamycin ara-C, consequently patients leukemia.